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PhD Seminar – Identification of genetic markers involved in development of cancer in Israeli Druze community

August 12 @ 12:00 - 14:00 IDT

Breast and Colorectal cancer are the leading tumor types in both Jews and Arabs in Israel. Genome-wide Association international studies (GWAS) revealed novel genetic markers for breast and colorectal cancer susceptibility, but little is known about the risk factors and molecular events associated with breast and colorectal cancer in the Druze Population. The aim of the current study is to measure the prevalence of multiple genetic variants among the Druze community from different sources (Lebanon, Syria, and Israel) and to study the association of these variants with breast and colorectal cancer risk in the Druze community. We hypothesize that the prevalence of genetic variants involved in breast and colorectal cancer risk will be unique among the Druze community members and different from other communities. Our study included 176 participants for the breast cancer study (93 cases with breast cancer, 83 controls) and 196 participants for the colorectal cancer study (119 cases with colorectal cancer, 77 controls). DNA was extracted from blood samples and analyzed using the Illumina OncoArray chip ~535,000 SNPs. We characterized 89 associated breast cancer SNPs for the breast cancer participants and 43 associated colorectal cancer SNPs for the colorectal cancer participants. Identification of these genetic drivers in Druze could lead to increase surveillance and early detection leading to reduce incidence and mortality from breast and colorectal cancer.


August 12
12:00 - 14:00
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